Specifications
Chemical Name: Insulin-Like Growth Factor-1, Long R3 (IGF-1 LR3)
Molecular Formula: C400H625N111O115S9
Molecular Weight: ~9.1 kDa
Sequence: 83-aa IGF-1 analog with Arg3 substitution and 13-aa N-terminal extension; retains two disulfide bonds (A/B-chain–like fold)
Physical Appearance: White to off-white lyophilized powder
Container: 3 mL Type I glass vial (1 mg net content)
Purity: ≥ 99% (verified by HPLC & MS; third-party tested)
Intended Use: Laboratory research (RUO). Not for human or animal consumption.
Description
What is IGF-1 LR3?
IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg³) is a synthetic analog of insulin-like growth factor-1, engineered for increased molecular stability and prolonged biological activity in research environments.
Compared to native IGF-1, IGF-1 LR3 has been structurally modified to reduce binding to insulin-like growth factor binding proteins (IGFBPs). This modification allows researchers to study extended IGF-1 signaling and receptor interaction dynamics without rapid degradation or sequestration.
IGF-1 LR3 is widely used in laboratory research focused on cellular growth signaling, tissue regeneration mechanisms, and metabolic pathway analysis.
What does IGF-1 LR3 do?
In preclinical and laboratory research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), a key regulator of cellular growth, differentiation, and survival. Activation of this receptor initiates intracellular signaling pathways involved in protein synthesis, glucose metabolism, and cellular proliferation.
Because of its extended half-life and reduced affinity for binding proteins, IGF-1 LR3 allows researchers to examine sustained IGF-1 receptor activation over longer timeframes compared to endogenous IGF-1. This makes it a valuable tool for studying downstream anabolic signaling, recovery-associated processes, and tissue remodeling pathways.
Research interest commonly includes:
• Cellular growth and proliferation signaling
• Protein synthesis and anabolic pathway activation
• Muscle cell differentiation and repair models
• Glucose uptake and metabolic regulation
• Interaction between IGF-1 and growth hormone–mediated pathways
Unlike compounds that stimulate upstream hormone release, IGF-1 LR3 acts directly at the receptor level, enabling focused investigation into IGF-1–specific mechanisms.
Research Context
IGF-1 LR3 is often evaluated in controlled research settings alongside compounds that influence growth hormone signaling, such as GHRH analogs or GHRPs, to explore the relationship between upstream GH release and downstream IGF-1 activity.
All references to signaling activity, biological effects, or pathway modulation are based on laboratory and preclinical research models only.
Storage & Handling
Storage Before Reconstitution (Lyophilized Peptide)
Unreconstituted (lyophilized) peptides should be stored cold and dry to prevent degradation.
• Short-term storage: 2°C–8°C (36°F–46°F) — standard laboratory refrigeration
• Long-term storage: –20°C (–4°F) or colder
Storage After Reconstitution
Once reconstituted, peptides become more sensitive to temperature, light, and contamination.
• Refrigerated storage: 2°C–8°C (36°F–46°F) for short-term research use
• Frozen storage (if required by protocol): –20°C (–4°F)
Handling best practices:
• Avoid repeated temperature changes.
• Minimize vial access and unnecessary agitation
• Keep protected from light
Return Policy
Due to the nature of our products, all sales are final. We do not accept returns, exchanges, or refunds once an order has been shipped.
Terms & Conditions of Use
By accessing this website or purchasing any product from Pure Source Peptide, you agree to the following Terms & Conditions of Use.
Research Use Only (RUO)
All products sold on this website are designated Research Use Only (RUO). Products are supplied solely for laboratory and educational research purposes and are not intended for human or animal consumption. These products are not approved by the U.S. Food and Drug Administration (FDA) for diagnostic, therapeutic, medical, dietary, or veterinary use and have not undergone clinical evaluation for safety or efficacy.
Eligibility to Purchase
By placing an order, you confirm that:
• You are at least 21 years of age
• You are a qualified professional, institution, or individual conducting legitimate research
• You possess the appropriate knowledge, facilities, and equipment to handle research chemicals safely and responsibly
Prohibited Use
You agree not to use, distribute, resell, or represent any product purchased from this website:
• For human or animal use
• For diagnostic, therapeutic, or medical purposes
• As a dietary supplement, drug, cosmetic, or household product
• In violation of any local, state, federal, or international laws or regulations
Any misuse of products assumes all associated risk and voids any eligibility for claims or support.
